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Approach to hypoglycemia in infants and children

Agneta Sunehag, MD, PhD
Morey W Haymond, MD
Section Editor
Joseph I Wolfsdorf, MB, BCh
Deputy Editor
Alison G Hoppin, MD


In healthy individuals, maintenance of a normal plasma glucose concentration depends upon:

A normal endocrine system for integrating and modulating substrate mobilization, interconversion, and utilization

Functionally intact enzymes for glycogenolysis, glycogen synthesis, glycolysis, gluconeogenesis, and utilization of other metabolic fuels for oxidation and storage

An adequate supply of endogenous fat, glycogen, and potential gluconeogenic substrates (eg, amino acids, glycerol, and lactate)

Adults are capable of maintaining a near-normal blood glucose concentration, even when totally deprived of calories for weeks or, in the case of obese subjects, months [1]. In contrast, healthy neonates and young children are unable to maintain normal plasma glucose concentrations after even a short fast (24 to 36 hours) and exhibit a progressive decline in plasma glucose concentration to hypoglycemic values [2,3].


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Literature review current through: Feb 2015. | This topic last updated: Sep 11, 2013.
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