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Antiplatelet agents in acute non-ST elevation acute coronary syndromes

Authors
Michael Simons, MD
Donald Cutlip, MD
A Michael Lincoff, MD
Section Editors
Christopher P Cannon, MD
Freek Verheugt, MD, FACC, FESC
Deputy Editor
Gordon M Saperia, MD, FACC

INTRODUCTION

Rupture of an atherosclerotic plaque is the usual initiating event in an acute coronary syndrome. Plaque rupture often leads to thrombus formation and persistent thrombotic occlusion results in acute myocardial infarction (MI). This topic will review the evidence that antiplatelet therapy is beneficial in patients with an acute non-ST elevation MI (NSTEMI) or unstable angina and will provide recommendations for its use. Information regarding antiplatelet agents in ST elevation MI and the role of anticoagulant therapy in NSTEMI are discussed separately. (See "Antiplatelet agents in acute ST elevation myocardial infarction" and "Anticoagulant therapy in non-ST elevation acute coronary syndromes".)

Other relevant topics include:

(See "The role of the vulnerable plaque in acute coronary syndromes".)

(See "Congenital and acquired disorders of platelet function", section on 'Normal platelet function'.)

(See "The role of platelets in coronary heart disease".)

                        

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Literature review current through: Nov 2016. | This topic last updated: Wed Sep 28 00:00:00 GMT 2016.
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