Antiphospholipid syndrome and the kidney
- Gerald B Appel, MD
Gerald B Appel, MD
- Section Editor — Glomerular Diseases
- Professor of Medicine
- Columbia University College of Physicians and Surgeons
- Section Editors
- Richard J Glassock, MD, MACP
Richard J Glassock, MD, MACP
- Editor-in-Chief — Nephrology
- Section Editor — Glomerular Diseases
- Emeritus Professor
- The David Geffen School of Medicine at UCLA
- Peter H Schur, MD
Peter H Schur, MD
- Editor-in-Chief — Rheumatology
- Section Editor — Basic Science
- Professor of Medicine
- Harvard Medical School
The antiphospholipid syndrome (APS) is characterized by antibodies directed against either phospholipids or plasma proteins bound to anionic phospholipids. Patients with the APS may display a constellation of clinical features including venous and arterial thrombosis, recurrent fetal losses, and thrombocytopenia. This disorder is referred to as the primary APS when it occurs alone; however, it can also be found in association with systemic lupus erythematosus (SLE), other rheumatic diseases, and certain infections and drugs.
Types of antiphospholipid antibodies (aPL) that have been characterized include:
●Antibodies causing a false-positive Venereal Disease Research Laboratory (VDRL) test
●Anticardiolipin antibodies (aCL)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- RENAL MANIFESTATIONS OF ANTIPHOSPHOLIPID SYNDROME
- Renal disease in primary antiphospholipid syndrome
- Other glomerular lesions associated with primary antiphospholipid syndrome
- Renal disease in antiphospholipid syndrome associated with systemic lupus erythematosus
- ANTIPHOSPHOLIPID SYNDROME IN END-STAGE RENAL DISEASE
- Renal transplantation
- Renal transplantation
- Acute kidney injury
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