Antiphospholipid syndrome and the kidney
- Gerald B Appel, MD
Gerald B Appel, MD
- Section Editor — Glomerular Diseases
- Professor of Medicine
- Columbia University College of Physicians and Surgeons
- Section Editors
- Richard J Glassock, MD, MACP
Richard J Glassock, MD, MACP
- Editor-in-Chief — Nephrology
- Section Editor — Glomerular Diseases
- Emeritus Professor
- The David Geffen School of Medicine at UCLA
- Peter H Schur, MD
Peter H Schur, MD
- Editor-in-Chief — Rheumatology
- Section Editor — Basic Science
- Professor of Medicine
- Harvard Medical School
The antiphospholipid syndrome (APS) is characterized by antibodies directed against either phospholipids or plasma proteins bound to anionic phospholipids. Patients with the APS may display a constellation of clinical features including venous and arterial thrombosis, recurrent fetal losses, and thrombocytopenia. This disorder is referred to as the primary APS when it occurs alone; however, it can also be found in association with systemic lupus erythematosus (SLE), other rheumatic diseases, and certain infections and drugs.
Four types of antiphospholipid antibodies (aPL) have been characterized:
●Antibodies causing a false-positive Venereal Disease Research Laboratory (VDRL) test
●Anticardiolipin antibodies (aCL)
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- RENAL MANIFESTATIONS OF ANTIPHOSPHOLIPID SYNDROME
- Renal disease in primary antiphospholipid syndrome
- Other glomerular lesions associated with primary antiphospholipid syndrome
- Renal disease in antiphospholipid syndrome associated with systemic lupus erythematosus
- ANTIPHOSPHOLIPID SYNDROME IN END-STAGE RENAL DISEASE
- Renal transplantation
- Renal transplantation
- Acute kidney injury
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS