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Antimicrobial therapy of prosthetic valve endocarditis

Adolf W Karchmer, MD
Section Editor
Stephen B Calderwood, MD
Deputy Editor
Elinor L Baron, MD, DTMH


Infection of a prosthetic heart valve can be difficult to diagnose and manage. Optimal treatment of prosthetic valve endocarditis (PVE) requires:

Identification of the causative microorganism

Selection of a bactericidal antimicrobial regimen of proven efficacy

A clear understanding of the intracardiac pathology and attendant complications of PVE

Surgical intervention, especially when infection has extended beyond the valve to contiguous cardiac tissue


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Literature review current through: Jul 2015. | This topic last updated: Apr 1, 2015.
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