Antenatal depression: Risks of cognitive impairment and psychopathology in the offspring
- Sophie Grigoriadis, MD, MA, PhD, FRCPC
Sophie Grigoriadis, MD, MA, PhD, FRCPC
- Associate Professor of Psychiatry
- University of Toronto
- Sunnybrook Health Sciences Centre
- Section Editors
- Peter P Roy-Byrne, MD
Peter P Roy-Byrne, MD
- Editor-in-Chief — Psychiatry
- Section Editor — Depressive Disorders
- Professor of Psychiatry and Behavioral Sciences
- University of Washington School of Medicine
- Charles J Lockwood, MD, MHCM
Charles J Lockwood, MD, MHCM
- Section Editor — Obstetrics
- Senior Vice President, USF Health
- Dean, Morsani College of Medicine
- Professor, Obstetrics and Gynecology
- University of South Florida
Antenatal depression is associated with cognitive impairment and psychopathology in the offspring. The cognitive dysfunction includes delay in acquiring language skills. In addition, the risk of aggressive behavior, anxiety, depression, and hyperactivity is increased in the offspring of depressed mothers, compared with the offspring of nondepressed mothers.
This topic reviews the association between antenatal depression and cognitive impairment and psychopathology in the children. The association between antenatal depression and pregnancy and neonatal outcomes as well as abnormal infant and child development is discussed separately, as are the risks of prenatal antidepressants, and the clinical features, assessment, diagnosis, and treatment of antenatal depression:
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- QUALITY OF EVIDENCE
- POTENTIAL MECHANISMS
- General cognitive functioning
- Emotional and behavioral dysfunction
- - Aggressive and antisocial behavior
- - Anxiety
- - Autism
- - Depression
- - Hyperactivity
- PREGNANCY AND NEONATAL OUTCOMES
- ABNORMAL INFANT AND CHILD DEVELOPMENT
- RISKS OF ANTIDEPRESSANTS
- POSTPARTUM DEPRESSION
- INFORMATION FOR PATIENTS