Medline ® Abstract for Reference 95
of 'Anemia in children due to decreased red blood cell production'
B19 parvovirus infection in children with malignant solid tumors receiving chemotherapy.
Rao SP, Miller ST, Cohen BJ
Med Pediatr Oncol. 1994;22(4):255.
Two children with rhabdomyosarcoma developed severe anemia following chemotherapy; anemia was more severe compared to that observed following earlier chemotherapy cycles. While one patient had a brisk reticulocytosis, the other had no demonstrable reticulocytes. Both patients had evidence of acute B19 parovirus infection and subsequently developed appropriate antibody response. A diagnosis of B19 parvovirus infection should be considered in any patient who develops persistent or severe anemia while on chemotherapy.
Department of Pediatrics, SUNY Health Science Center, Brooklyn, NY 11203.