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Medline ® Abstract for Reference 129

of 'Anemia in children due to decreased red blood cell production'

Hematopoietic stem cell transplantation in children with genetic defects.
Nair V, Das S, Sharma A
Indian Pediatr. 2009;46(3):241.
Seventeen children (mean age: 7.2 years) with genetic defects involving hematopoietic cell production or function, underwent 19 allogeneic stem cell transplantations from HLA identical siblings. Twelve children were suffering from thalassemia major; 2 from Diamond Blackfan anemia; 2 from Fanconi anemia and 1 from congenital dyserythropoietic anemia. The disease free survival was 77% with a mean follow up of 36 months. The major complications were graft versus host disease, veno-occlusive disease, CMV infection and hemorrhage. One case each of thalassaemia major and Fanconi anemia rejected the graft after 1 year and 11 months, respectively. Both patients were successfully transplanted second time from the same donor with some modification in the conditioning regimen and stem cell source.
Department of Haematology and Bone Marrow Transplantation, Army Hospital Research and Referral, Delhi Cantonment, Delhi, India. nairvelu2000@yahoo.com