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Medline ® Abstract for Reference 80

of 'Anaphylaxis: Emergency treatment'

H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review.
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A
Ann Allergy Asthma Immunol. 2014 Feb;112(2):126-31. Epub 2013 Dec 5.
BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.
OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.
METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.
RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.
CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.
Allergy&Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh, Edinburgh, United Kingdom. Electronic address: Ulugbek.Nurmatov@ed.ac.uk.