Anaphylaxis: Confirming the diagnosis and determining the cause(s)
- John M Kelso, MD
John M Kelso, MD
- Section Editor – Anaphylaxis
- Division of Allergy, Asthma, and Immunology
- Scripps Clinic, San Diego, CA
Anaphylaxis is a potentially life-threatening emergency that requires immediate diagnosis and treatment. (See "Anaphylaxis: Emergency treatment".)
Patients who have experienced anaphylaxis (or suspected anaphylaxis) require evaluation to confirm the diagnosis and determine the cause(s) and possible contributing factors, such as other medical conditions (comorbidities) and concurrent medications.
REFERRAL TO AN ALLERGY/IMMUNOLOGY SPECIALIST
Referral to a board-certified allergy specialist is indicated in all cases of certain or suspected anaphylaxis [1-5]. A thorough evaluation is required to accomplish the following objectives:
●Confirm the diagnosis
●Confirm or determine the cause
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- REFERRAL TO AN ALLERGY/IMMUNOLOGY SPECIALIST
- CONFIRMING THE DIAGNOSIS OF ANAPHYLAXIS
- History of exposures and activities
- - Comorbidities
- - Concurrent medications and other substances
- Review of treatment
- Laboratory test results obtained at the time of anaphylaxis
- TESTING FOR ALLERGEN CAUSE(S)
- Sensitization to allergens
- Testing for related allergies
- THE PATIENT WITH AN IDENTIFIABLE CAUSE
- THE PATIENT WITH NO IDENTIFIABLE CAUSE
- DIFFERENTIAL DIAGNOSIS OF ANAPHYLAXIS
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS