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Allergy testing in eosinophilic esophagitis

Jonathan M Spergel, MD, PhD, FAAAAI
Section Editor
Scott H Sicherer, MD, FAAAAI
Deputy Editor
Elizabeth TePas, MD, MS


Eosinophilic esophagitis (EoE) was defined by a panel of experts as "a chronic, immune/antigen-mediated, esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation" [1]. Allergy testing in EoE is warranted to identify and manage common comorbid atopic diseases (eg, asthma, allergic rhinitis) and to determine foods that may present a risk for acute allergic reactions/immediate-type allergy (this is a concern for many patients with EoE at baseline and also when eliminated foods are potentially reintroduced into the diet during treatment). It may also help identify EoE triggers.

The evidence supporting the role of allergies in EoE and the various types of allergy testing used are reviewed here. Other aspects of disease pathogenesis, clinical manifestations, general diagnostic evaluation, and treatment (including choosing a specific elimination diet) are reviewed separately. (See "Clinical manifestations and diagnosis of eosinophilic esophagitis" and "Treatment of eosinophilic esophagitis" and "Dietary management of eosinophilic esophagitis" and "Patient education: Eosinophilic esophagitis (The Basics)".)


Several lines of evidence suggest that allergies play a significant role in EoE. An immune response to allergen/antigen is a primary factor in the pathogenesis of the disease, and there is evidence that both environmental allergies and food allergies are involved. In addition, the majority of patients with EoE are atopic, with asthma, allergic rhinitis, atopic dermatitis, and/or immunoglobulin E (IgE)-mediated food allergy.

Mechanistic studies — Evidence for allergies in EoE is supported by murine models that show that skin sensitization protocols can induce eosinophilic inflammation in the esophagus when that organ is challenged [2-4]. In addition, examination of esophageal samples has indicated that classic allergic cytokines and chemokines (interleukin [IL]-4, IL-5, IL-13, eotaxin-3) are involved in the pathogenesis of EoE [1,4-7]. Additional details on the pathogenesis of EoE are discussed separately. (See "Eosinophilic esophagitis (EoE): Genetics and immunopathogenesis", section on 'Pathogenesis'.)

Clinical response to dietary changes — The evidence for the role of food allergies in the pathogenesis of EoE is based upon the clinical response when patients are placed on various elimination diets, with resolution of symptoms and normalization of esophageal biopsies. The data are equally extensive and convincing in children and adults. This evidence is discussed in detail separately. (See "Dietary management of eosinophilic esophagitis", section on 'Role of food allergy in EoE'.)

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Literature review current through: Nov 2017. | This topic last updated: Apr 28, 2017.
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