Medline ® Abstracts for References 4,5
of 'Alcoholic cardiomyopathy'
The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men.
Urbano-Márquez A, Estruch R, Fernández-SoláJ, Nicolás JM, ParéJC, Rubin E
OBJECTIVE: To compare the cardiac and muscular status of male and female alcoholics to determine if the response of women to alcohol is different from that of men.
DESIGN: Cross-section study.
SETTING: An ambulatory alcoholism treatment unit in the Hospital Clínic of Barcelona.
PATIENTS: Fifty asymptomatic alcoholic women, 100 asymptomatic alcoholic men, and 50 female nonalcoholic controls.
MAIN OUTCOME MEASURES: Studies included clinical assessment of muscle strength, muscle biopsy, echocardiography, radionuclide cardiac angiography, and treadmill exercise electrocardiographic recording test.
RESULTS: The mean strength of the deltoid muscle in alcoholic women was significantly lower than that in controls (P<.001) and half suffered clinical weakness (muscle strength>or = 2 SD below controls). Muscle biopsy specimens from half of all asymptomatic women showed histologic evidence of myopathy. Left ventricular ejection fractions tended to be depressed, and a third of the alcoholic women had evidence of cardiomyopathy. Muscular strength and ejection fractions in women were inversely correlated with the total lifetime dose of ethanol, whereas the left ventricular mass showed a direct correlation. Of the alcoholic men, 39% suffered clinical weakness, and 45% had histologic evidence of myopathy. Evidence of cardiomyopathy was found in almost a third of the men, and their ejection fractions also correlated inversely with the total lifetime dose of ethanol. However, the threshold dose for the development of cardiomyopathy was considerably less in women than in men, and the decline in the ejection fraction with increasing alcohol dose was significantly steeper (P<.001).
CONCLUSIONS: Despite the fact that the mean lifetime dose of alcohol in female alcoholics was only 60% that in male alcoholics, cardiomyopathy and myopathy were as common in female alcoholics as in male alcoholics. This finding, together with a more pronounced response of the ejection fraction to the dose of ethanol, indicates that women are more sensitive than men to the toxic effects of alcohol on striated muscle.
Department of Internal Medicine and Cardiology, Hospital Clínic, University of Barcelona, Spain.
Comparison of alcoholic cardiomyopathy in women versus men.
Fernández-SolàJ, Estruch R, Nicolás JM, ParéJC, Sacanella E, Antúnez E, Urbano-Márquez A
Am J Cardiol. 1997;80(4):481.
To compare the prevalence and cardiac status of male and female alcoholics with alcoholic cardiomyopathy during a 5-year period, all chronic alcoholics with dilated cardiomyopathy who had clinical symptoms of heart failure were included. Alcoholic cardiomyopathy was diagnosed in 10 chronic alcoholic women and in 26 men; the prevalence of alcoholic cardiomyopathy was similar in both sexes. No significant differences were observed in age, nutritional parameters, and clinical and radiologic data of heart failure between the 2 groups. Alcoholic women reported a significantly lower daily dose of ethanol (p = 0.002), a shorter duration of alcoholism (p = 0.017), and a lower total lifetime dose of ethanol consumption (p = 0.001), and had a lower New York Heart Association functional class than men. Women also had lesser ventricular dysfunction than men. In a multivariate analysis, left ventricular systolic dysfunction was related to the total lifetime dose of ethanol consumption (p<0.04), but not to gender. Finally, when patients were matched for left ventricular ejection fraction, women had consumed a lower total lifetime dose of ethanol than men (p<0.001). The prevalence of alcoholic women with dilated cardiomyopathy was found to be similar to that of alcoholic men, although women required a lower total lifetime dose of ethanol to develop the disease.
Department of Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.