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Advanced sleep-wake phase disorder

Author
Katherine M Sharkey, MD, PhD
Section Editor
Cathy A Goldstein, MD
Deputy Editor
April F Eichler, MD, MPH

INTRODUCTION

Advanced sleep-wake phase disorder (ASWPD) is a circadian rhythm sleep-wake disorder in which sleep quality and duration are normal but sleep onset and wake times are earlier than desired or earlier than socially acceptable times. Patients often force themselves to stay awake in the evenings but continue to wake up early, thereby accumulating sleep debt and excessive daytime sleepiness.

The clinical features, evaluation, and treatment of ASWPD will be reviewed here. An overview of circadian sleep-wake rhythm disorders and a more general approach to the patient with excessive daytime sleepiness are presented separately. (See "Overview of circadian sleep-wake rhythm disorders" and "Approach to the patient with excessive daytime sleepiness".)

EPIDEMIOLOGY

The incidence and prevalence of advanced sleep-wake phase disorder (ASWPD) are not well established. Based on a few large survey studies examining sleep timing and symptoms of ASWPD, the disorder may be more prevalent among older adults and men [1-5].

One study estimated a prevalence of 0.25 to 7 percent among more than 4000 adults aged 20 to 59 years using various definitions of ASWPD derived from a self-administered questionnaire [6]. At least two population-based studies have found that men express more of a preference for later sleep-onset times and shorter sleep durations than women, suggesting that men may be more distressed by a persistent pattern of early sleep than women [5,7].

PATHOPHYSIOLOGY

Clock genes and familial ASWPD — A genetic basis for advanced sleep-wake phase disorder (ASWPD) in some individuals is supported by several well-characterized families with ASWPD inherited in an autosomal-dominant, highly penetrant pattern [8-10].

              

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Literature review current through: Nov 2016. | This topic last updated: Tue Dec 06 00:00:00 GMT 2016.
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