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Advanced non-small cell lung cancer: Subsequent systemic therapy for previously treated patients

Author
Rogerio C Lilenbaum, MD, FACP
Section Editor
Howard J West, MD
Deputy Editor
Sadhna R Vora, MD

INTRODUCTION

Initial systemic therapy (chemotherapy or targeted agents) may delay disease progression and prolong survival in patients with advanced non-small cell lung cancer (NSCLC). However, almost all patients eventually develop progressive disease requiring further treatment.

Advances in the use of chemotherapy, targeted agents, and immunotherapy have led to the sequential use of multiple lines of therapy. The choice and sequence of subsequent therapies will be presented here.

The initial management of advanced NSCLC is presented separately. (See "Overview of the treatment of advanced non-small cell lung cancer".)

Further details regarding the rationale and data supporting the use of immunotherapy and targeted therapies are discussed elsewhere:

(See "Immunotherapy of non-small cell lung cancer with immune checkpoint inhibition".)

                            
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Literature review current through: Oct 2017. | This topic last updated: Oct 03, 2017.
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