Adjuvant therapy of early stage (stage I and II) epithelial ovarian, fallopian tubal, or peritoneal cancer
- Thomas J Herzog, MD
Thomas J Herzog, MD
- Clinical Director
- University of Cincinnati Cancer Institute
- Section Editors
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Professor of Gynecologic Oncology
- University of Washington
- Don S Dizon, MD, FACP
Don S Dizon, MD, FACP
- Section Editor – Gynecologic Oncology
- Clinical Co-Director, Gynecologic Oncology
- Founder and Director, The Oncology Sexual Health Clinic
- Massachusetts General Hospital Cancer Center
- Associate Professor of Medicine
- Harvard Medical School
Epithelial cancers of ovarian, fallopian tubal, and peritoneal origin exhibit similar clinical characteristics and behavior. As such, these are often combined and define epithelial ovarian cancer (EOC) in clinical trials and clinical practice. This topic will consider all three tumor origins under the heading EOC.
EOC is the most common cause of death among women with gynecologic malignancies and the fifth leading cause of cancer death in women in the United States. Only approximately 25 percent of women will be diagnosed with early stage ovarian cancer, either confined to the ovary (stage I) or confined to the pelvis (stage II). For women with EOC confined to the ovary (IA or IB) and/or well-differentiated (grade 1) tumors, prognosis is excellent with survival of at least 90 percent following surgery alone [1,2]. For all others, adjuvant chemotherapy is recommended.
This section will review adjuvant therapy for early stage EOC. Initial surgical management, adjuvant therapy for women with advanced (stage III or IV) ovarian cancer, and chemotherapy for women with recurrent disease are discussed separately.
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- SELECTION OF PATIENTS
- CHOICE OF ADJUVANT TREATMENT
- Intravenous chemotherapy
- SPECIAL CONSIDERATIONS
- Clear cell histology
- Unstaged patients
- Intraperitoneal chemotherapy
- Maintenance therapy
- POSTTREATMENT SURVEILLANCE
- TREATMENT OF RECURRENT DISEASE
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS