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Medline ® Abstract for Reference 31

of 'Adjuvant therapy for resected stage III (node-positive) colon cancer'

31
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Does delay of adjuvant chemotherapy impact survival in patients with resected stage II and III colon adenocarcinoma?
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Bayraktar UD, Chen E, Bayraktar S, Sands LR, Marchetti F, Montero AJ, Rocha-Lima CM
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Cancer. 2011;117(11):2364.
 
BACKGROUND: It is unclear whether delays in commencing adjuvant chemotherapy after surgical resection of colon adenocarcinoma adversely impact survival.
METHODS: Patients with stage II-III colon adenocarcinoma who received adjuvant chemotherapy at 2 centers were identified through the institutional tumor registry. Time to adjuvant chemotherapy, overall survival (OS), and relapse-free survival (RFS) were calculated from the day of surgery. Patients were dichotomized into early (time to adjuvant chemotherapy≤60 days) and late treatment (time to adjuvant chemotherapy>60 days) groups. OS and RFS were compared using log-rank test and multivariate analysis by the Cox proportional hazards model.
RESULTS: Of 186 patients included in the study, 49 (26%) had received adjuvant chemotherapy>60 days after surgical resection. Thirty percent of the delays were system related (eg, late referrals, insurance authorizations). Time to adjuvant chemotherapy>60 days was associated with significantly worse OS in both univariate analysis and aCox proportional hazards model (hazard ratio, 2.17; 95% confidence interval, 1.08-4.36). Although difference in RFS between the 2 groups favored time to adjuvant chemotherapy<60, this did not reach statistical significance.
CONCLUSIONS: Adjuvant chemotherapy delay>60 days after surgical resection of colon cancer is associated with worse OS.
AD
Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida. ubayraktar@med.miami.edu.
PMID