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Medline ® Abstract for Reference 116

of 'Adjuvant therapy for resected stage III (node-positive) colon cancer'

Adjuvant postoperative radiotherapy for colon carcinoma.
Mendenhall WM, Amos EH, Rout WR, Zlotecki RA, Hochwald SN, Cance WG
Cancer. 2004;101(6):1338.
BACKGROUND: The objective of this report was to review the role of adjuvant postoperative radiotherapy (RT) for patients with adenocarcinoma of the colon.
METHODS: The authors reviewed the pertinent literature.
RESULTS: Data suggested that locoregional postoperative RT improves both local control and survival for patients with T4N0-N1 tumors. There also may be a benefit for patients with T3N1-N2 tumors, but the data were equivocal. Whole abdominal RT may result in a similar benefit but is associated with increased toxicity.
CONCLUSIONS: Postoperative RT should be considered for patients with T4N0-N1 colon carcinoma. Locoregional fields should be used.
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32610, USA. mendewil@shands.ufl.edu