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Medline ® Abstract for Reference 86

of 'Adjuvant radiation therapy for women with newly diagnosed, non-metastatic breast cancer'

86
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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
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Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C, Sands A, Eichele G, Hasty P, Bradley A
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Nature. 1997;386(6627):804.
 
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.
AD
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
PMID