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Adjuvant endocrine therapy for non-metastatic, hormone receptor-positive breast cancer

Kathleen I Pritchard, MD, FRCPC
Section Editor
Daniel F Hayes, MD
Deputy Editor
Sadhna R Vora, MD


Breast cancer is the most frequently diagnosed cancer and the leading cause of death from cancer in women worldwide. In the United States, breast cancer is the most common female cancer, the second most common cause of cancer death in women, and the main cause of death in women ages 40 to 49 years. Breast cancer is a heterogeneous, phenotypically diverse disease composed of several biologic subtypes that have distinct behavior and response to therapy. Hormone receptor-positive (ie, estrogen [ER] and/or progesterone [PR] receptor-positive) breast cancers comprise the most common types of breast cancer, accounting for 75 percent of all cases.

This topic will review adjuvant endocrine therapy for non-metastatic, hormone receptor-positive breast cancer occurring in women. Other topics, including the adjuvant treatment of hormone receptor-negative breast cancer, human epidermal growth factor receptor 2 (HER2)-positive breast cancer, male breast cancer, and triple-negative breast cancer, are covered separately. In addition, a discussion on the role of osteoclast inhibitors in the adjuvant treatment of breast cancer is covered separately.

(See "Overview of the treatment of newly diagnosed, non-metastatic breast cancer".)

(See "Adjuvant chemotherapy for HER2-negative breast cancer".)

(See "Adjuvant systemic therapy for HER2-positive breast cancer".)

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Literature review current through: Nov 2017. | This topic last updated: Dec 08, 2017.
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