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Acute kidney injury (acute renal failure) in the newborn

Tej K Mattoo, MD, DCH, FRCP
Section Editors
Richard Martin, MD
F Bruder Stapleton, MD
Deputy Editor
Melanie S Kim, MD


Acute kidney injury (AKI), formerly referred to as acute renal failure (ARF), is defined as an abrupt reduction in kidney function measured by a rapid decline in glomerular filtration rate. AKI is an important contributing factor to the morbidity and mortality of critically ill neonates.

AKI results in the disturbance of the following renal physiological functions:

Impairment of nitrogenous waste product excretion

Loss of water and electrolyte regulation

Loss of acid-base regulation


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Literature review current through: Mar 2017. | This topic last updated: May 08, 2015.
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