Acute generalized exanthematous pustulosis (AGEP)
- Alexis Sidoroff, MD
Alexis Sidoroff, MD
- Professor of Dermatology and Venereology
- Medical University of Innsbruck, Austria
- Chia-Yu Chu, MD, PhD
Chia-Yu Chu, MD, PhD
- Associate Professor - Department of Dermatology
- National Taiwan University Hospital
- Section Editors
- Jean-Claude Roujeau, MD
Jean-Claude Roujeau, MD
- Section Editor — Drug Eruptions
- Emeritus Professor of Dermatology
- Université Paris-Est Créteil (UPEC), Créteil, France
- Maja Mockenhaupt, MD, PhD
Maja Mockenhaupt, MD, PhD
- Section Editor — Drug Eruptions
- Professor of Dermatology
- Medical Center - University of Freiburg, Germany
Acute generalized exanthematous pustulosis (AGEP) is a rare, acute eruption characterized by the development of numerous nonfollicular sterile pustules on a background of edematous erythema (picture 1A) [1,2]. Fever and peripheral blood leukocytosis are usually present.
In approximately 90 percent of cases, AGEP is caused by drugs, most often antibiotics (eg, aminopenicillins and macrolides), antifungals, the calcium channel blocker diltiazem, and antimalarials . The eruption develops within hours or days of drug exposure and resolves spontaneously in one to two weeks after drug discontinuation.
AGEP will be discussed in this topic. Other types of cutaneous drug reactions and pustular eruptions are discussed separately.
●(See "Drug eruptions".)
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- ETIOLOGY AND PATHOGENESIS
- Eliciting factors
- Immunologic mechanisms
- CLINICAL FEATURES
- CLINICAL COURSE
- Clinical and histologic
- Laboratory tests
- DIFFERENTIAL DIAGNOSIS
- Drug withdrawal and supportive measures
- Symptomatic treatment
- SUMMARY AND RECOMMENDATIONS