Acute generalized exanthematous pustulosis (AGEP) is a rare, acute eruption characterized by the development of numerous nonfollicular sterile pustules on a background of edematous erythema (picture 1A-B) [1,2]. Fever and peripheral blood leukocytosis are usually present.
In approximately 90 percent of cases, AGEP is caused by drugs, most often antibiotics (eg, aminopenicillins and macrolides), calcium channel blockers (eg, diltiazem), and antimalarials . The eruption develops within hours or days of drug exposure and resolves spontaneously in one to two weeks after drug discontinuation.
AGEP will be discussed in this topic. Other types of cutaneous drug reactions and pustular eruptions are discussed separately.
●(See "Drug eruptions".)
●(See "Exanthematous (morbilliform) drug eruption".)