A variety of proliferative, inflammatory, and infiltrative conditions are associated with enlarged or giant mucosal folds in the stomach (diffuse mucosal hypertrophy) . These conditions have a similar appearance despite primary involvement of the mucosa, submucosa, or both in specific conditions. Thus, the underlying cause of the large mucosal folds cannot be determined from gross observation alone.
In one series, endoscopic snare biopsy was performed in 52 patients with large gastric folds (greater than 1.0 cm in width and persisting after air insufflation) . The diagnoses included the following:
●Chronic gastritis/lymphoid hyperplasia – 40 percent
●Benign tumors – 16 percent
●Gastric malignancy – 12 percent