Large gastric folds: Hyperplastic and nonhyperplastic gastropathies
- Mark Feldman, MD, MACP, AGAF, FACG
Mark Feldman, MD, MACP, AGAF, FACG
- Section Editor — Acid Peptic Disease
- Texas Health Presbyterian Hospital Dallas
- Clinical Professor of Internal Medicine
- University of Texas Southwestern Medical School at Dallas
- Pamela J Jensen, MD
Pamela J Jensen, MD
- Attending Pathologist
- Texas Health Presbyterian Hospital Dallas
A variety of proliferative, inflammatory, and infiltrative conditions are associated with enlarged or giant mucosal folds in the stomach (diffuse mucosal hypertrophy) . These conditions have a similar appearance despite primary involvement of the mucosa, submucosa, or both in specific conditions. Thus, the underlying cause of the large mucosal folds cannot be determined from gross observation alone.
In one series, endoscopic snare biopsy was performed in 52 patients with large gastric folds (greater than 1.0 cm in width and persisting after air insufflation) . The diagnoses included the following:
●Chronic gastritis/lymphoid hyperplasia – 40 percent
●Benign tumors – 16 percent
●Gastric malignancy – 12 percent
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- HYPERPLASTIC GASTROPATHIES
- Ménétrier's disease
- - Pathogenesis
- - Clinical manifestations
- - Diagnosis
- - Treatment
- - Prognosis
- Zollinger-Ellison syndrome
- LARGE GASTRIC FOLDS ASSOCIATED WITH OTHER CONDITIONS
- H. pylori gastritis
- Gastric neoplasia
- Miscellaneous causes
- SUMMARY AND RECOMMENDATIONS