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Medline ® Abstract for Reference 31

of 'Acquired TTP: Clinical manifestations and diagnosis'

Sudden cardiac death from thrombotic thrombocytopenic purpura.
Wajima T, Johnson EH
Clin Appl Thromb Hemost. 2000;6(2):108.
Clinical thrombotic thrombocytopenic purpura (TTP) is characterized by a pentad of microangiopathic hemolytic anemia, thrombocytopenia, neurological symptoms, renal involvement, and fever. A case of TTP in which early symptoms and signs were suggestive of ischemic heart disease, renal failure, and severe thrombocytopenia developed to a rapid outcome of death. The postmortem examination revealed coronary artery microthrombi, typical of TTP. The clinical presentation of this TTP was atypical: severe thrombocytopenia, striking renal and CNS symptoms were present, but fever and anemia were not present. Thrombotic thrombocytopenic purpura is an uncommon condition that carries a high fatality rate if untreated. Awareness of this syndrome and its high risk of sudden death underlines the importance of rapid diagnosis and treatment.
Texas A&M University Health Science Center College of Medicine and Central Texas Veterans Health Care System, Temple 76504, USA. wajimaty@aol.com