Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Medline ® Abstract for Reference 33

of 'A short primer on cost-effectiveness analysis'

Recommendations for the Conduct and Reporting of Modeling and Simulation Studies in Health Technology Assessment.
Dahabreh IJ, Trikalinos TA, Balk EM, Wong JB
Ann Intern Med. 2016;165(8):575. Epub 2016 Sep 20.
Models and simulations are valuable tools for addressing the uncertainty, tradeoffs, and heterogeneous preferences that complicate research questions in health technology assessment. This article presents recommendations for the conduct and reporting of modeling and simulation studies based on a systematic review of published recommendation statements, a survey of Web sites of international health technology assessment organizations, and input from experts and other stakeholders. The recommendations apply to mathematical models that represent structural relationships among model components and integrate information from multiple sources; they address model identification, estimation, verification, and validation, as well as the conduct of sensitivity, stability, and uncertainty analyses. They are organized into model conceptualization and structure, data, model assessment and consistency, and interpreting and reporting results. They should contribute to increased use and better conduct and reporting of modeling and simulation studies in health technology assessment.
From Brown University, Providence, Rhode Island, and Tufts Medical Center, Boston, Massachusetts.